Blood T-cell receptor b chain transcriptome in multiple sclerosis. Characterization of the T cells with altered CDR3 length distribution
نویسندگان
چکیده
1Institut National de la Sante et de la Recherche MeÂdicale (INSERM) Unite 437: `Immunointervention dans les Alloet XeÂnotransplantations', Institut de Transplantation et de Recherche en Transplantation (ITERT), CHU HoÃtel Dieu, 30 Bd Jean Monnet, 2Clinique Neurologique and Centre d'Investigation Clinique, HoÃpital G. et R. Laennec, Bd J. Monod, 3TcLand S.A., 30 Bd Jean Monnet, 44093 Nantes Cedex and 4Service de Neurologie, HoÃpital Pontchaillou, 35000, Rennes, France Correspondence to: Jean-Paul Soulillou, INSERM U437, 30 Bd Jean-Monnet, 44093 Nantes Cedex 01, France E-mail: [email protected]
منابع مشابه
Blood T-cell receptor beta chain transcriptome in multiple sclerosis. Characterization of the T cells with altered CDR3 length distribution.
Multiple sclerosis is an inflammatory demyelinating disease of the CNS associated with T cells autoreactive for myelin components. In this study, we analysed the T-cell receptor (TCR) usage of the variable beta (Vbeta) chain transcriptome in the blood of multiple sclerosis patients at various stages of the disease using a global and quantitative comparison of the complementarity-determining reg...
متن کاملStatistical analysis of CDR3 length distributions for the assessment of T and B cell repertoire biases.
Complementarity-determining region 3 (CDR3) length distribution analysis explores the diversity of the T cell receptor (TCR) and immunoglobulin (Ig) repertoire at the transcriptome level. Studies of the CDR3, the most hypervariable part of these molecules, have been frequently used to identify recruitment of T and B cell clones involved in immunological responses. CDR3 length distribution analy...
متن کاملExpression of Chemokine Receptors on Th1/Th2 CD4+ Lymphocytes in Patients with Multiple Sclerosis
Background: Th1 cells preferentially express CXCR3, CCR5 and CCR6, while CCR3 and CCR4 are predominantly expressed by Th2 cell subsets. Multiple Sclerosis (MS) is a Th1 cell-dependant chronic inflammatory disease of the central nervous system, and immunomudolatory cytokines could alter the chemokine expression pattern of these lymphocyte subsets. Objective: This study was performed to measure c...
متن کاملCharacterization of CD8+ T cell repertoire in identical twins discordant and concordant for multiple sclerosis.
Autoreactive CD4+ and CD8+ T cells directed against CNS autoantigens may play a role in the development of multiple sclerosis (MS). Identical twins share the same genetic background but not the TCR repertoire that is shaped by the encounter with self or foreign antigens. To gain insights into the interplay between MS and T cell repertoire, peripheral blood CD4+ and CD8+ T lymphocytes and their ...
متن کاملMiR-9-5p and miR-106a-5p dysregulated in CD4+ T-cells of multiple sclerosis patients and targeted essential factors of T helper17/regulatory T-cells differentiation
Objective(s): Multiple sclerosis (MS) is considered as a chronic type of an inflammatory disease characterized by loss of myelin of CNS.Recent evidence indicates that Interleukin 17 (IL-17)-producing T helper cells (Th17 cells) population are increased and regulatory T cells (Treg cells) are decreased in MS. Despite extensive research in understanding the mechanism of Th17 and Treg differentiat...
متن کامل